Open Access Research article

Daily versus intermittent iron supplementation in pregnant women

Zinatossadat Bouzari12, Zahra Basirat3, Mahtab Zeinal Zadeh3, Shahla Yazdani Cherati3, Maryam Didehdar Ardebil45, Maedeh Mohammadnetaj6 and Shahnaz Barat7*

Author Affiliations

1 Department of Obstruction & Gynecology, Babol University of Medical Science, Babol, Iran

2 Stem Cell Research Center, Babol University of Medical Science, Babol, Iran

3 Department of Obstruction & Gynecology, Babol University of Medical Science, Babol, Iran

4 Azad Islamic University, Sarab, Iran

5 Department of Psychology, Panjab University, India

6 Mazandaran University, Iran

7 Department of Obstruction & Gynecology, Babol University of Medical Science, Babol, Iran

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BMC Research Notes 2011, 4:444  doi:10.1186/1756-0500-4-444

Published: 25 October 2011

Abstract

Background

The purpose of this study was compare of daily iron supplementation in three time frames- daily, weekly and three time weekly supplementation in preventing anemia in healthy pregnant women.

Method

The present study was a prospective simply randomized clinical trial. During January 2006- January 2008, 150 healthy pregnant women without anemia, in their 16th week of pregnancy were randomly allocated into three equal groups. The first group (n = 50) received a 50 mg-ferrous sulfate tablet daily, second group (n = 50) received a 50 mg-ferrous sulfate tablet three times a week, and the third group (n = 50) received two 50 mg-ferrous sulfate tablets (100 mg) weekly, respectively for 12 consecutive weeks. Serum hemoglobin, ferritin, and iron were measured before and after the supplementation. Paired t and ANOVA tests were used as appropriated.

Results

There were no significant differences between the pre- and post-treatment hemoglobin levels with iron supplementation in the three group (P = 0.518, P = 0.276, respectively). The mean serum iron level before and after treatment with iron supplementation in the three groups was not statistically significant (P = 0.962, P = 0.970, respectively). Although the mean serum ferritin level before and after treatment with iron supplementation was statistically significant in the three groups, no significant differences were found comparing the three groups (P = 0.827, P = 0.635 respectively).

Conclusions

This results suggested, three times a week or weekly iron supplementation is as effective as daily supplementation for healthy pregnant women without anemia.

Trial Registration

ISRCTN: IRCT201101093820N1