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Open Access Research article

Serum selenium levels do not differ in type 2 diabetic subjects with and without coronary artery disease

Alexios Sotiropoulos1, Stavroula A Papadodima1, Athanasia K Papazafiropoulou1*, Aggelos Ioannidis2, Athanasia Kokkinari2, Ourania Apostolou1, Chara A Spiliopoulou2 and Sotirios Athanaselis2

Author Affiliations

1 3rd Department of Internal Medicine and Center of Diabetes, General Hospital of Nikaia "Ag. Panteleimon" - Piraeus, Greece

2 Department of Forensic Medicine and Toxicology, National and Kapodistrian University of Athens, Greece

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BMC Research Notes 2011, 4:270  doi:10.1186/1756-0500-4-270

Published: 29 July 2011

Abstract

Background

The aim of the present study was to investigate whether selenium levels differ between type 2 diabetic subjects with and without coronary artery disease (CAD).

Methods

A total of 200 subjects with type 2 diabetes (100 with CAD and 100 without CAD), consecutively selected from the diabetes outpatient clinic of our hospital were enrolled into the study. A detailed medical history and a physical examination were obtained by all the participants.

Results

Serum selenium levels did not differ between diabetic subjects with and without CAD (102.40 ± 31.10 vs. 108.86 ± 33.88 microg/L, p = 0.16). In diabetic subjects with CAD multivariate linear regression analysis demonstrated significant independent associations between selenium and sex (beta = 0.21, p = 0.03) and glucose levels (beta = 0.25, p = 0.008). In diabetic subjects without CAD multivariate linear regression analysis demonstrated significant independent associations between selenium and peripheral artery disease (beta = 0.16, p = 0.05) and glucose levels (beta = -0.09, p = 0.05).

Conclusion

Serum selenium levels did not differ between diabetic subjects with and without CAD. In diabetic subjects with CAD, the only determinants of serum selenium levels were sex and glucose levels. In diabetic subjects without CAD the only determinants of serum selenium levels were peripheral artery disease and glucose levels.

Keywords:
selenium; type 2 diabetes; cardiovascular disease