Table 2

Details of accepted trials

Article

DS

Study design

GIC treatment group

Resin treatment group

Outcome measure

Evaluation

Dentition/Teeth/Restoration

Study period



Type of material

BSL

N

n

LTF

Type of material

BSL

N

n

LTF

Criteria

Method


Dichotomous datasets

Oba et al., 2009 [32]

01

SM

Ketac Molar

91

56

6

35

Fissurit F

116

81

8

35

Caries

Caries present

Visual

First permanent molars

3 years

Barja-Fidalgo et al., 2009 [33]

02

PG

Fuji IX

46

46

1

0

Delton

46

46

2

0

Caries

Cavity that had clearly penetrated the dentin or if a radiolucency in dentin could be seen on the bitewing X- ray

Visual and X-Ray

First permanent molars

6 months

03

46

21

2

25

46

28

7

18

5 years

Karlzén-Reuterving and van Dijken, 1995 [20]

04

SM

Fuji III

74

72

1

2

Delton

74

72

3

2

Caries

Caries present

Visual

First permanent molars

3 years

Arrow and Riordan, 1995 [21]

05

SM

Ketac Fil

465

412

6

53

Delton

465

412

31

53

Caries

When a cavity was present

Visual

First permanent molars

Mean 3.64 (SD 0.11) years

Williams et al., 1996 [22]

06

SM

Fuji III

430

295

19

135

Delton

430

295

4

135

Caries

Caries present

Visual

First permanent molars

2 years

07

430

222

22

208

430

222

16

208

4 years

Rock et al., 1996 [23]

08

SM

Baseline

172

160

3

12

Fluoro- Shield

172

162

0

10

Caries

Caries present

Visual

First permanent molars

6 months

09

172

157

6

15

172

158

1

14

1 year

10

172

130

14

42

172

132

2

40

2 years

11

172

124

18

48

172

129

3

43

3 years

Kerrvanto- Seppälä et al., 2008 [24]

12

SM

Fuji III

1025

657

27

368

Delton

1025

657

7

368

Caries

If dentine caries was detected

Visual

2nd permanent molars

3 years

Beiruti et al., 2006

15

PG

Fuji IX

180

180

0

0

Visio Seal

180

180

1

0

Caries

Caries present

Visual

First permanent molars

1 year

[26]

16

180

154

0

26

180

161

6

19

2 years

17

180

154

3

26

180

138

13

42

3 years

18

180

143

7

37

180

123

21

57

4 years

19

180

80

8

100

180

76

27

104

5 years

Poulsen et al., 2006 [27]

20

SM

Fuji III

364

364

34

0

Delton

364

364

10

0

Radiograp-hically carious

Lesions into dentine

X-Ray

First permanent molars

2.3 - 3.2 years

21

364

364

23

0

364

364

10

0

Clinically carious

Danish municipal dental service criteria

Visual

Forss and Halme, 19981 [28]

22

SM

Fuji III

166

97

23

69

Delton

166

97

16

69

Caries

Caries lesion present/Arrested caries present

Visual

Permanent molars/premolars

7 years

Mejàre and Mjör, 1990 [29]

24

SM

Fuji III

44

36

0

8

Delton

117

75

6

42

Caries

Caries present

Visual

Permanent molars/premolars

5 years

25

44

36

0

8

Concise

47

18

2

29

Boksmann et al., 1987 [30]

26

SM

Fuji III

125

116

0

9

Concise

122

115

0

7

Caries

Caries present

Visual

Permanent molars

6 months

Poulsen et al., 2001 [31]

27

SM

Fuji III

170

116

44

54

Delton

170

116

13

54

Caries

White, yellow, brown discoloration of the fissure or cavity

Visual

First permanent molars

3 years

Forss et al., 19941 [37]

28

SM

Fuji III

166

151

7

15

Delton

166

151

7

15

Caries

Caries lesion present/Arrested caries present

Visual

Permanent molars/premolars

2 years

Williams and Winter, 1981 [38]

30

SM

ASPA

No info

4862

642

No info

Concise

No info

4862

932

No info

Caries

Caries present

Visual

First permanent molars

3.84 years

Article

DS

Continuous datasets

Patient character-istics/potential confounders*

Type of material

N

x

SD

LTF

Type of material

N

x

SD

LTF

Outcome measure

Criteria

Method

Dentition/Teeth/Restoration

Study period

Songpaisan et al., 1995 [25]

13

PG

Fuji III

128

0.48

1.03

14%

Delton

133

0.05

0.57

14%

DFS increment

DFS

Visual

Permanent molars

2 years

14

128

1.82

2.60

133

0.98

1.72

DMFS increment

DMFS

Forss and Halme, 19981 [28]

23

SM

Fuji III

97

0.13

0.40

69

Delton

97

0.13

0.37

69

Caries increment on approximal tooth surfaces adjacent to materials

Caries lesion present/Arrested caries present

Visual

Permanent molars/premolars

7 years

Forss et al., 19941 [37]

29

SM

Fuji III

151

0.09

0.34

15

Delton

151

0.13

0.41

15

2 years

Article

Place of trial

Age of patients

Patient characteristics/inclusion/exclusion criteria

Fluoride exposure from other sources

Oba et al., 2009 [32]

Study conducted in a boarding school in the city of Kırıkkale/Turkey

7-11 years

Children received instructions on good oral health care and were individually shown how to clean their teeth prior to the start of the treatment; inclusion criteria were: (1) sound pits and fissures in fully erupted first molars; and (2) pits and fissures diagnosed with an early enamel lesion; exclusion criteria were: (1) partly erupted first molar; (2) an obvious cavity in the occlusal surface; and (3) the presence of a restoration or a sealant (or part of it) in the pit and fissure system;

Resin-based fissure sealant material containing fluoride

Barja-Fidalgo et al., 2009 [33]

Study carried out in the Department of Paediatric Dentistry, Rio de Janeiro State University, Rio de Janeiro/Brazil;

mean age 6.8 years (±0.98 SD)

With at least 1 permanent first molar erupted and 2 or more primary molars decayed, filled, or extracted due to caries; most from low socio-economic background with high caries-risk; the participants were also given oral hygiene instructions and dietary counselling; those who had dental care needs were referred to the paediatric dental clinic for appropriate restorative and surgical treatment; participants reported brushing their teeth daily, 11% reported using dental floss regularly, and 67% had a dental check-up once a year first molars that presented a sound occlusal surface or occlusal caries at the D1 level (non-cavitated enamel lesion) entered the study; low patient compliance and high saliva contamination during treatment reported.

-

Karlzén-Reuterving and van Dijken, 1995 [20]

Children from Umea/Sweden

mean age 7 years, 1 month

Teeth without clinical evidence of caries were sealed

-

Arrow and Riordan, 1995 [21]

Children from Perth/Australia

mean age 7 (SD 0.72) years

With sound, unsealed, homologous 1st permanent molars

-

Williams et al., 1996 [22]

Children from Suffolk/UK

6-8 years

Recently erupted visually caries free 1st permanent molars; resealed teeth were excluded

Fluoride concentration of drinking water 0.1 - 0.5 mgF/l

Rock et al., 1996 [23]

Children from Tamworth, Staffordshire/UK

7-8 years

Caries free fully erupted 1st permanent molars; children had evidence of caries in primary teeth

The resin-based sealant FluroShield contains fluoride; fluoride concentration of drinking water 0.13 ppm

Kerrvanto- Seppälä et al., 2008 [24]

Children from Varkaus/Finland

12-16 years

2nd permanent molars considered to be at risk of caries were sealed; teeth with lost resin sealant were resealed and not excluded from the study.

-

Beiruti et al., 2006 [26]

Children from Damascus/Syria

mean age 7.8 years

No cavities in primary teeth; inclusion criteria: sound pits and fissures in fully erupted 1st permanent molars, pits and fissures with early enamel lesion and/or small dentinal lesion; exclusion criteria: partly erupted tooth, obvious occlusal cavity, presence of restoration or sealant in pits and fissures.

-

Poulsen et al., 2006 [27]

Children from Vaerlose/Denmark

8-13 years

Mean DMFS was between 0.5 and 0.7 for 12-year-old children and between 1.4 and 1.8 for 13-year-old children; sound surfaces, and surfaces with initial or arrested caries (white or brown fissures) were sealed, if the dentist's clinical assessment indicated a caries risk; only children with both clinical and radiographic data were included in the present study

Fluoride content of the drinking water 0.25 ppm; all children commonly use fluoridated toothpaste

Forss and Halme, 2006 [28]

Children from Raisio/Finland

5-14 years

Contra-lateral pair of newly erupted non-sealed permanent molars or premolars

-

Mejàre and Mjör, 1990 [29]

-

mean age 9.2 (5.7 - 15.0) years

-

-

Boksmann et al., 1987 [30]

-

6-18 years

Patients had not received topical fluoride treatment for at least 3 months prior.

Fluoride content of the drinking water 1 ppm or more

Poulsen et al., 2001 [31]

Children from Damascus/Syria

7 years

Only children with at least one pair of caries free permanent 1st molars or with incipient lesions; average DMFT 0.6 -0.7.

-

Forss et al., 1994 [37]

Children from Raisio/Finland

5-14 years

Contra-lateral pair of newly erupted non-sealed permanent molars or premolars

-

Williams and Winter, 1981 [38]

-

6-8 and 11-13 years

-

-

Songpaisan et al., 1995 [25]

Children from Bangkok/Thailand

12-13 years

From very low to medium socio-economic background; children with at least 3 sound permanent molars (erupted sufficiently)

Included in a fluoride mouth rinse programme (0.2% NaF) every 2 weeks; fluoride concentration of drinking water 0.1 - 0.2 ppm


DS = Dataset number; BSL = Number of teeth at baseline; N = Number of teeth evaluated; n = Number of teeth with caries, LTF = Loss-to-follow-up; x = Mean; SD = Standard deviation; PG = Parallel group design; SM = Split-mouth design.

1 Different datasets reported from same trial

2 Number of pits reported, instead of the number of sealed teeth

* Potential confounders = Reported fluoride exposure; high-sugary diet; poor oral hygiene; high past caries experience.

Mickenautsch and Yengopal BMC Research Notes 2011 4:22   doi:10.1186/1756-0500-4-22

Open Data