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Open Access Short Report

Epidemiology of vampire bat-transmitted rabies virus in Goiás, central Brazil: re-evaluation based on G-L intergenic region

Shinji Hirano1, Takuya Itou1*, Adolorata AB Carvalho2, Fumio H Ito3 and Takeo Sakai1

Author Affiliations

1 Nihon University Veterinary Research Center, 1866 Kameino, Fujisawa 252-0880, Kanagawa, Japan

2 Faculty of Agriculture and Veterinary Science, Department of Preventive Veterinary Medicine, UNESP, Via de Acesso Prof. Paulo Donato Castellane, Jaboticabal, São Paulo 14884-900, Brazil

3 Department of Preventive Veterinary Medicine and Animal Health, Faculty of Veterinary Medicine and Zootechny, University of São Paulo, Av. Prof. Dr. Orlando Marques de Paiva, 87, Cidade Universtiátria, São Paulo 05508-000, Brazil

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BMC Research Notes 2010, 3:288  doi:10.1186/1756-0500-3-288

Published: 8 November 2010

Abstract

Background

Vampire bat related rabies harms both livestock industry and public health sector in central Brazil. The geographical distributions of vampire bat-transmitted rabies virus variants are delimited by mountain chains. These findings were elucidated by analyzing a high conserved nucleoprotein gene. This study aims to elucidate the detailed epidemiological characters of vampire bat-transmitted rabies virus by phylogenetic methods based on 619-nt sequence including unconserved G-L intergenic region.

Findings

The vampire bat-transmitted rabies virus isolates divided into 8 phylogenetic lineages in the previous nucleoprotein gene analysis were divided into 10 phylogenetic lineages with significant bootstrap values. The distributions of most variants were reconfirmed to be delimited by mountain chains. Furthermore, variants in undulating areas have narrow distributions and are apparently separated by mountain ridges.

Conclusions

This study demonstrates that the 619-nt sequence including G-L intergenic region is more useful for a state-level phylogenetic analysis of rabies virus than the partial nucleoprotein gene, and simultaneously that the distribution of vampire bat-transmitted RABV variants tends to be separated not only by mountain chains but also by mountain ridges, thus suggesting that the diversity of vampire bat-transmitted RABV variants was delimited by geographical undulations.