Schematic transcript and protein representation of NOD2 and its isoforms NOD2-S as well as NOD2-C2. The novel NOD2-C2 transcript contains an additional exon 3a highlighted in black. Contrary to NOD2-S, NOD2-C2 has a reconstructed second CARD domain, which differs in the last 9 amino acid compared to exon 3-4 spliced NOD2.
Kramer et al. BMC Research Notes 2010 3:224 doi:10.1186/1756-0500-3-224