Distribution of the L- and H-signatures in colon and rectal cancer (TCGA_CRC) and endometrial carcinoma (TCGA_EC). X-axis: sample indexes. Y-axis: relative coefficient of the signature. In the L-signature, samples with a microsatellite stable status (MSS, red dots) or low levels of a microsatellite instable status (MSI-L, green dots) have high coefficients in both colon and rectal cancer (A) and endometrial carcinoma samples (B). In the H-signature, samples with high levels of MSI (MSI-H, blue dots) have high coefficient in both colon and rectal cancer (C) and endometrial carcinoma samples (D). Samples with POLE mutations were denoted by large circles.
Jia et al. BMC Medical Genomics 2014 7:11 doi:10.1186/1755-8794-7-11