Table 3

Sensitivities and Specificities (Multivariable Models)

Method (Model)1

Sensitivity (95% CI)

Sensitivity (LOOCV)3

Specificity (95% CI)4

Specificity (LOOCV)


stepPLR (λ = 0.1) (male only, with age)

89.92(85.69-95.80)

89.08

83.82(73.53-91.18)

82.35

stepPLR (λ = 1) (male only, with age)

90.76(86.55-95.81)

89.92

86.76(77.94-94.12)

82.35

stepPLR (λ = 10) (male only, with age)

90.75(86.56-95.81)

88.24

88.24(75.00-92.65)

83.82

stepPLR (λ = 0.1) (male only, without age)

84.87(79.83-90.76)

84.03

80.88(70.59-89.71)

79.41

stepPLR (λ = 1) (male only, without age)

84.82(78.15-90.76)

83.19

83.82(75.00-92.65)

77.94

stepPLR (λ = 10) (male only, without age)

84.03(78.15-91.60)

84.03

85.29(76.47-92.65)

83.82

stepPLR (λ = 0.1) (gender, with age)

89.94(84.91-94.39)

89.94

86.67(80.00-92.38)

83.81

stepPLR (λ = 1) (gender, with age)

90.57(86.16-94.94)

89.31

86.67(80.00-93.33)

86.66

stepPLR (λ = 10) (gender, with age)

89.31(84.28-93.71)

88.68

88.57(81.90-94.29)

88.58

stepPLR (λ = 0.1) (gender, without age)

86.16(86.50-91.19)

84.91

84.76(77.14-91.43)

84.76

stepPLR (λ = 1) (gender, without age)

85.53(79.87-90.57)

84.90

85.71(80.00-93.33)

84.76

stepPLR (λ = 10) (gender, without age)

84.27(79.87-90.57)

81.76

86.66(80.00-92.38)

86.66

mob(AAT|~.) with age, male only)

90.43(79.36-95.63)

86.96

81.82(73.45-88.33)

77.27

mob(GP73|~.) with age, male only)

88.69(77.51-94.61)

86.08

86.36(78.39-91.83)

80.30

mob(AFP|~.) with age, male only)

93.04(83.20-98.32)

84.34

83.33(75.41-89.75)

75.76

mob(Kin|~.) with age, male only)

91.30(81.26-96.59)

86.96

78.79(67.71-83.92)

84.85

mob(AAT|~.) without age, male only)

88.23(82.35-93.28)

78.15

77.94(67.65-86.76)

72.06

mob(GP73|~.) without age, male only)

85.71(79.83-92.44)

81.51

70.59(60.29-80.88)

67.64

mob(AFP|~.) without age, male only)

86.55(80.67-92.44)

79.83

66.17(54.41-76.47)

60.29

mob(Kin|~.) without age, male only)

92.43(87.39-96.64)

90.75

80.88(70.59-89.71)

75.00

mob(AAT|~.) with age, gender)

89.33(84.28-93.71)

86.16

85.71(79.05-92.38)

77.14

mob(GP73|~.) with age, gender)

94.97(91.82-98.11)

92.45

86.68(80.00-92.38)

80.00

mob(AFP|~.) with age, gender)

91.19(86.75-94.97)

88.05

83.81(76.19-90.48)

76.19

mob(Kin|~.) with age, gender)

94.39(90.54-97.48)

89.30

80.95(73.33-80.95)

74.28

mob(AAT|~.) without age, gender)

88.67(84.28-93.71)

87.42

81.90(74.29-88.57)

80.00

mob(GP73|~.) without age, gender)

83.64(77.36-89.31)

82.39

89.52(83.81-95.24)

84.76

mob(AFP|~.) without age, gender)

88.05(83.65-93.08)

87.42

80.95(73.33-88.65)

76.19

mob(Kin|~.) without age, gender)

91.82(88.05-96.45)

89.93

81.90(75.24-88.60)

77.14


1. Method utilized for analysis, stepPLR stepwise penalized logistic regression with or without age and/or gender, mob model-based CART, classification and regression trees developed with or without age and/or gender; 2) optimal sensitivity and 95% Confidence interval; 3) Optimal sensitivity following leave one out cross validation; 4) Optimal specificity; 5) Optimal specificity following leave one out cross validation.

Wang et al. BMC Medical Genomics 2013 6(Suppl 3):S9   doi:10.1186/1755-8794-6-S3-S9

Open Data