Disease annotation vs. corrected MeSHOP comparison score. The figure displays a heatmap depicting the number of drug-disease tuples for a disease annotation level (MeSH terms attached to the disease MeSHOP) on the x-axis and a corrected MeSHOP comparison score on the y-axis. MeSHOP similarity scores were calculated using L2 distance, but were corrected as described in the text to account for background annotation levels. The degree of disease annotation, measured as the total number of distinct MeSH terms associated with a disease, is no longer correlated (Pearson correlation score of 0.08) once corrected.
Cheung et al. BMC Medical Genomics 2013 6(Suppl 2):S3 doi:10.1186/1755-8794-6-S2-S3