Table 1

The 28 significant pathways analysed using ClueGO.

Significant Pathways

Specific To cluster

Adjust P-Value

Total number

Gene source


unique SCZ gene count

unique T2D gene count

Common gene count


Adipocytokine signaling pathway

T2D

3.91E-09

18

4

12

2

Neuroactive ligand-receptor interaction

SCZ

4.01E-09

35

26

9

0

Maturity onset diabetes of the young

T2D

1.94E-08

11

0

11

0

Type II diabetes mellitus

T2D

1.98E-08

14

1

12

1

PPAR signaling pathway

T2D

9.33E-07

15

2

13

0

Calcium signaling pathway

SCZ

5.03E-06

23

18

5

0

Visceral Fat Deposits and the Metabolic Syndrome

T2D

6.57E-05

5

0

4

1

Type I diabetes mellitus

SCZ

7.12E-05

10

8

1

1

Corticosteroids and cardioprotection

BOTH

8.96E-05

6

3

2

1

Low-density lipoprotein (LDL) pathway during atherogenesis

T2D

3.28E-04

4

0

4

0

Insulin signaling pathway

T2D

9.20E-04

16

1

15

0

Graft-versus-host disease

SCZ

0.001587097

8

6

1

1

IL-10 Anti-inflammatory Signaling Pathway

BOTH

0.001671861

4

1

1

2

Basic mechanism of action of PPARa, PPARb(d) and PPARg and effects on gene expression

T2D

0.001780493

3

0

3

0

Actions of Nitric Oxide in the Heart

BOTH

0.002369651

5

2

3

0

Erythropoietin mediated neuroprotection through NF-kB

BOTH

0.003426765

4

2

1

1

Allograft rejection

SCZ

0.003509

7

5

0

2

g-Secretase mediated ErbB4 Signaling Pathway

SCZ

0.005740212

3

3

0

0

Msp/Ron Receptor Signaling Pathway

BOTH

0.005740212

3

1

1

1

Autoimmune thyroid disease

SCZ

0.020029548

7

6

0

1

Alzheimer's disease

BOTH

0.020096651

5

1

2

2

Free Radical Induced Apoptosis

SCZ

0.020961818

3

2

0

1

Role of PPAR-gamma Coactivators in Obesity and Thermogenesis

T2D

0.020961818

3

0

3

0

Asthma

SCZ

0.023911463

5

3

0

2

AKT Signaling Pathway

SCZ

0.024540904

4

3

1

0

Hematopoietic cell lineage

BOTH

0.027660527

9

4

4

1

Regulation of PGC-1a

T2D

0.029865431

3

1

2

0

Role of ERBB2 in Signal Transduction and Oncology

T2D

0.030339933

4

1

3

0


SCZ: schizophrenia; T2D: type 2 diabetes mellitus. The p-value is adjusted by Benjamini-Hochberg method.

Liu et al. BMC Medical Genomics 2013 6(Suppl 1):S17   doi:10.1186/1755-8794-6-S1-S17

Open Data