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This article is part of the supplement: Proceedings of the 2011 International Conference on Bioinformatics and Computational Biology (BIOCOMP'11)

Open Access Research

Exploring the pathogenetic association between schizophrenia and type 2 diabetes mellitus diseases based on pathway analysis

Yanli Liu1, Zezhi Li2, Meixia Zhang3, Youping Deng4, Zhenghui Yi5* and Tieliu Shi1*

Author Affiliations

1 Center for Bioinformatics and Computational Biology, and The Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China

2 Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, 168 Changhai Road, Shanghai, China

3 Department of Ophthalmology, West China Hospital, Sichuan University 37 Guoxuexiang, Chengdu, Sichuan, 610041, China

4 Rush University Cancer Center, Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USA

5 Schizophrenia Program, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 Wan Ping Nan Road, Shanghai 200030, China

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BMC Medical Genomics 2013, 6(Suppl 1):S17  doi:10.1186/1755-8794-6-S1-S17

Published: 23 January 2013

Additional files

Additional file 1:

196 SCZ and 200 T2D susceptibility gene sets.

Format: XLSX Size: 15KB Download file

Open Data

Additional file 2:

Pathway shared genes and their involved pathways.

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Additional file 3:

Protein-Protein Interaction Network. This network consists of 2,104 nodes and 3,155 edges, nodes represent proteins, node size stands for its degree, edges represent interaction between two proteins. Nodes in blue are 143 SCZ susceptibility proteins; nodes in green are 138 T2D susceptibility proteins; nodes in yellow are common susceptibility proteins; remainder nodes in purple are 1,811 candidate proteins.

Format: PDF Size: 195KB Download file

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Additional file 4:

Sub-network extracted from Additional file 3. This network consists of 580 nodes and 1,266 edges, node attributes refer to Additional file 3.

Format: PDF Size: 69KB Download file

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Open Data

Additional file 5:

Literature mining results for the 364 new candidate genes. 364 candidate genes are in the first column; the second column hosts the number of interactions from SCZ susceptibility proteins; the third column lists the PubMed ID for the reported protein associated with SCZ; the fourth column is the interactions of SCZ. The corresponding results of T2D are displayed in the following columns. Genes in pink background are 25 candidate genes which have been implicated in both SCZ and T2D with various studies.

Format: XLSX Size: 35KB Download file

Open Data