Table 3

Enriched pathways of differentially expressed genes

Rank

KEGG Path ID

KEGG pathway name

Top 5 loadings gene


1

path:hsa00670

One carbon pool by folate

"MTHFD2L" "ALDH1L1" "MTFMT" "ALDH1L2" "MTR"

2

path:hsa00590

Arachidonic acid metabolism

"PTGS2""GPX7" "PLB1" "CYP4A11""GPX2"

3

path:hsa04910

Insulin signaling pathway

"FLOT2" "PRKAB2""MAPK8" "PPP1R3B" "PIK3CB"

4

path:hsa05110

Vibrio cholerae infection

"TJP2" "ATP6V1C1" "ADCY9""ARF1" "ATP6V1H"

5

path:hsa04020

Calcium signaling pathway

"HTR4" "TRPC1""ADCY8""CHRM5""GRIN2A"

6

path:hsa00520

Amino sugar and nucleotide sugar metabolism

"CHI3L1" "HK2""NPL""HEXA" "UAP1L1"

7

path:hsa04062

Chemokine signaling pathway

"CXCL5""CXCL10" "PF4V1""CCL8" "CXCL11"

8

path:hsa00640

Propanoate metabolism

"MLYCD" "ALDH2" "ACSS1" "PCCB""ALDH3A2"

9

path:hsa00500

Starch and sucrose metabolism

"UGT2B17" "UGT2B15" "MGAM""HK1" "AMY2B"

10

path:hsa00240

Pyrimidine metabolism

"DPYD""ENTPD1""TXNRD1""TK2" "TYMP"


Top Ten Enriched Pathways of most Factor Loading Genes. KEGG Path ID represents for KEGG pathway ID[ 19], which is ranked by pvalues of enrichment analysis. Pathways in gray lines have at least one bold marked gene, which is selected as a feature in gene based classifier. And the pathways in gray lines are the pathways that directly linked with diabetes r by the marked genes.

Zhao et al. BMC Medical Genomics 2013 6(Suppl 1):S12   doi:10.1186/1755-8794-6-S1-S12

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