Table 2

Bias due to the order of gene expression values.

Class/Range

C1

C2

C3

Class/Range

C1

C2

C3


R1

3

0

0

R1

3

0

0

R2

0

88

0

R2

4

0

0

R3

4

0

0

R3

0

88

0

R4

0

0

5

R4

0

0

5


In this example, we consider the goodness ranking of two genes in a dataset with 100 patients and 3 classes of cancer sub-types. The expression values of the genes were discretized into 4 ranges R1, R2, R3 and R4. There are 4 patients in class C1 with expression values of gene #1 in the range R3, 88 patients in class C2 with expression values of gene #1 in the range R2, and so on.

Tran BMC Medical Genomics 2013 6(Suppl 1):S11   doi:10.1186/1755-8794-6-S1-S11

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