Table 1

Top 10 genes associated with MSI
Mutation alone Methylation alone Integrated data
Rank Gene Sign Gene Sign Gene Sign
1 TGFBR2 MLH1 MLH1 (methyl)
2 CASP8 FLVCR2 PDE6B (mut)
3 ACVR2A EFNA1 POLR1D (mut)
4 MSH3 CDK12 FLVCR2 (methyl)
5 MAP3K6 HOXC11 DAK (mRNA)
6 GATA2 ZNF318 TGFBR2 (mut)
7 MACF1 SEPT5 SEPT5 (methyl)
8 BRAF MIER3 EFNA1 (methyl)
9 GPHN ELK4 MLH1 (mRNA)
10 MAEA SDHD STK32B (mut)

Gene ranking is based on the regression coefficient (see Methods). Genomic assay and associated feature is indicated in parentheses for integrative analysis of the combined genomic data. The symbol ↑ indicates increased frequency (mutation) or level (methylation) in MSI. The symbol ↓ indicates decreased frequency (mutation) or level (methylation, gene expression) in MSI.

Lee et al.

Lee et al. BMC Medical Genomics 2013 6:54   doi:10.1186/1755-8794-6-54

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