Table 1

Statistics of genetic modifiers in NeuroGeM
Species Disease models Experimental records Modifiers1 Gene coverage2 (%)
Positive records Negative records Enhancers Suppressors Non-modifiers
D. melanogaster ADTau 144 571 65 60 549 4.89
AD 61 6062 25 22 6059 44.43
PD 1 - - 1 - 0.01
HD 1260 8142 130 90 7732 57.82
SCA1 66 24 16 21 21 0.42
SCA3 623 52 55 520 49 4.54
SCA7 14 19 8 5 18 0.23
PolyQ 22 44 7 10 43 0.44
C. elegans ADTau 75 15909 - 75 15899 97.86
AD 6 - 1 5 - 0.04
HD 22 2 1 17 2 0.12
PD 290 18121 - 268 15767 98.24
ALS 168 15909 88 80 15817 97.92
PolyQ 459 40 152 195 20 2.11
S. cerevisiae AD 106 5262 18 23 5248 78.83
HD 82 9422 28 54 4670 70.83
PD 216 4699 22 181 4577 71.26
PolyQ 1 - - 1 - 0.01

1Certain genes have been identified independently as both an enhancer and suppressor under different experimental conditions.

2With respect to the protein coding genes.

Na et al.

Na et al. BMC Medical Genomics 2013 6:52   doi:10.1186/1755-8794-6-52

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