Common impairment marker genes across regions and diseases. Correlation between Impairment and gene expression in the hippocampus of Alzheimer’s disease is relatively consistent with correlation between impairment and gene expression in frontal cortex (A) and basal ganglia (B) of HIV-associated neurocognitive disorder. The x-axes represent correlation with GCR score in HIV brains, while the y-axes represent negative correlation with MMSE in the AD brains. Dots in the upper right of the plot represent genes whose increased expression in either HIV of AD would suggest impairment, while dots in the lower left represent genes whose decreased expression would suggest impairment.
Levine et al. BMC Medical Genomics 2013 6:4 doi:10.1186/1755-8794-6-4