Open Access Highly Accessed Research article

Systems analysis of human brain gene expression: mechanisms for HIV-associated neurocognitive impairment and common pathways with Alzheimer’s disease

Andrew J Levine1*, Jeremy A Miller2, Paul Shapshak3, Benjamin Gelman4, Elyse J Singer1, Charles H Hinkin56, Deborah Commins7, Susan Morgello8, Igor Grant9 and Steve Horvath102

Author Affiliations

1 Department of Neurology, National Neurological AIDS Bank, David Geffen School of Medicine at the University of California, Los Angeles, CA, USA

2 Department of Human Genetics, David Geffen School of Medicine at the University of California, Los Angeles, CA, USA

3 Department of Medicine (Division of Infectious Disease & International Medicine) and Department of Psychiatry & Behavioral Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA

4 Departments of Pathology and Neuroscience & Cell Biology, University of Texas Medical Branch, Galveston, USA

5 Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at the University of California, Los Angeles, CA, USA

6 VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA

7 Department of Pathology, Keck School of Medicine at the University of Southern California, Los Angeles, CA, USA

8 Departments of Neurology, Neuroscience, and Pathology, Manhattan HIV Brain Bank, The Mount Sinai School of Medicine, New York, USA

9 Department of Psychiatry, California NeuroAIDS Tissue Network, University of California, San Diego, USA

10 Department of Biostatistics, University of California, Los Angeles, CA, USA

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BMC Medical Genomics 2013, 6:4  doi:10.1186/1755-8794-6-4

Published: 13 February 2013

Additional files

Additional file 1:

Correlations between gene expression and clinical variables (CPE scores and neurocognitive impairment).

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Additional file 2:

Hub genes and gene ontology enrichment for all modules found among the four clinically/neuropathologically-defined groups.

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Additional file 3:

Gene ontology enrichment for the modules related to neurocognitive impairment in the frontal cortex.

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