Open Access Highly Accessed Research article

Genome-wide search for the genes accountable for the induced resistance to HIV-1 infection in activated CD4+ T cells: apparent transcriptional signatures, co-expression networks and possible cellular processes

Wen-Wen Xu13, Miao-Jun Han13, Dai Chen4, Ling Chen5, Yan Guo1, Andrew Willden6, Di-Qiu Liu1 and Hua-Tang Zhang12*

Author Affiliations

1 Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Jiaochang East Road 32, Kunming, Yunnan Province, 650223 China

2 Chongqing Center for Biomedical Research and Equipment Development, Chongqing Academy of Science and Technology, Chongqing, China

3 Graduate University of Chinese Academy of Sciences, Beijing, China

4 Novel Bioinformatics Co., Ltd, Shanghai, China

5 Yunnan centers for disease control and prevention, Kunming, China

6 Editorial Department, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China

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BMC Medical Genomics 2013, 6:15  doi:10.1186/1755-8794-6-15

Published: 1 May 2013

Additional files

Additional file 1: Figure S1:

Comparative CFSE staining among “R”, “P” and “B” cells. Cells of “R” were stained with CFSE and cells of “P” and “B” were stained with CFSE on day 3 and day 6. Significant T cell proliferation was observed during the culture period.

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Additional file 2: Figure S2:

Comparative Ki67 staining among “R”, “P” and “B” cells. Cells of “R” were stained with anti-Ki67 and cells of “P” and “B” were stained with anti-Ki67 on day 3 and day 6 and it also showed significant T cell proliferation during the culture period. Red line: isotype control; green line: Ki67.

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Additional file 3: Table S1:

Differentially expressed genes.

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Additional file 4: Table S2:

Profiles of differentially expressed genes.

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Additional file 5: Table S3:

Gene ontologies of the differentially expressed genes in “P” and “B” cells.

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Additional file 6: Table S4:

Hierarchical GO categories of genes involved in induced permissive “P” and resistant “B” cells.

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Additional file 7: Table S5:

Interactions between HIV-1 proteins and significant functional genes.

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