Table 5

Ten most down-regulated pathways in insulin-resistant compared to insulin-sensitive group during euglycemic hyperinsulinemic conditions

GO category

Pathway name

Nominal p

Permuted p


GO:0005746

mitochondrial respiratory chain

9.7E-06

0.0002


GO:0044429

mitochondrial part

1.3E-05

0.001


GO:0022900

electron transport chain

1.6E-05

0.0002


GO:0050890

cognition

2.6E-05

0.0005


GO:0016651

oxidoreductase activity, acting on NADH or NADPH

3.9E-05

0.0002


GO:0005759

mitochondrial matrix

4.9E-05

0.0008


GO:0031349

positive regulation of defense response

7.3E-05

0.0008


GO:0022891

substrate-specific transmembrane transporter activity

8.9E-05

0.0022


GO:0003954

NADH dehydrogenase activity

1.0E-04

0.0023


GO:0055114

oxidation reduction

1.1E-04

0.0037


Soronen et al. BMC Medical Genomics 2012 5:9   doi:10.1186/1755-8794-5-9

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