Table 1

Physical and biochemical characteristics of the study subjects divided into insulin-sensitive and -resistant groups on the basis of their median whole-body insulin sensitivity

Microarray

qPCR


Insulin Sensitive

Insulin Resistant

p value

Insulin

Sensitive

Insulin Resistant

pvalue


n

5

5

-

11

9

-


Age (years)

33 ± 6

39 ± 5

NS

32 ± 4

39 ± 3

NS


Body weight (kg)

60 ± 4

90 ± 5

0.009

69 ± 4

90 ± 5

0.003


BMI (kg/m2)

22.0 ± 0.7

32.5 ± 1.7

0.009

24.7 ± 1.1

33.0 ± 2.0

0.002


Whole-body fat (%)

24 ± 3

36 ± 1

0.009

28 ± 2

36 ± 1

0.002


Fat mass (kg)

15 ± 2

33 ± 3

0.009

20 ± 2

35 ± 4

0.003


Waist-to-hip ratio

0.86 ± 0.02

0.93 ± 0.02

0.047

0.86 ± 0.01

0.91 ± 0.01

0.03


fP-glucose (mmol/l)

5.0 ± 0.1

5.7 ± 0.2

0.016

5.1 ± 0.1

5.6 ± 0.2

0.012


fS-insulin (mU/l)

3 ± 0.5

11 ± 2

0.009

3 ± 0.4

10 ± 1

< 0.001


fS-LDL cholesterol (mmol/l)

2.2 ± 0.2

3.1 ± 0.2

0.016

2.2 ± 0.2

3.1 ± 0.2

0.004


fS-triglycerides (mmol/l)

0.9 ± 0.2

1.3 ± 0.2

0.076

0.78 ± 0.1

1.4 ± 0.2

0.002


fS-HDL cholesterol (mmol/l)

1.9 ± 0.09

1.4 ± 0.05

0.009

1.8 ± 0.08

1.4 ± 0.09

0.003


fS-C-peptide (nmol/l)

0.4 ± 0.03

0.8 ± 0.01

0.009

0.4 ± 0.03

0.8 ± 0.08

0.002


Data are mean ± SEM, fP = fasting plasma, fS = fasting serum

Soronen et al. BMC Medical Genomics 2012 5:9   doi:10.1186/1755-8794-5-9

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