Table 1

Frequencies of LOH, LOI and MOI in human ovarian cancers.

(A) Ovarian cancer tissues


H19/

R sal

IGF2/

Apal

KCNQ1/

Smal

LIT1/

R sal

GTL2/

T aal

PEG1/

AFlll

PEG3/

Mnll

NDN/

Mbol


Heterozygosity

58.5

(41/70)

47.1

(33/70)

55.5

(40/72)

16.2

(12/74)

58.3

(42/72)

50.0

(37/74)

34.2

(25/73)

41.8

(31/74)

LOH

4.8

(2/41)

9.0

(3/33)

5.0

(2/40)

0.0

(0/12)

7.1

(3/42)

8.1

(3/37)

4.0

(1/25)

0.0

(0/31)

LOI

29.2

(12/41)

45.4

(15/33)

12.5

(5/40)

16.6

(2/12)

23.8

(10/42)

45.9

(17/37)

8.0

(2/25)

6.4

(2/31)

MOI

56.0

(23/41)

33.3

(11/33)

77.5

(31/40)

83.3

(10/12)

66.6

(28/42)

45.9

(17/37)

84.0

(21/25)

93.5

(29/31)

ND

9.7

(4/41)

12.1

(4/33)

5.0

(2/40)

0.0

(0/12)

2.3

(1/42)

0.0

(0/37)

4.0

(1/25)

0.0

(0/31)

(B) Cell lines


Heterozygosity

19.0

(4/21)

14.2

(3/21)

33.3

(7/21)

14.39

(3/21)

23.8

(5/21)

42.8

(9/21)

23.8

(5/21)

23.8

(5/21)

LOI

0/4

2/3

3/7

1/3

2/5

3/9

0/5

0/5

MOI

4/4

1/3

4/7

2/3

3/5

6/9

5/5

5/5


Percents of LOH (loss of heterozygosity), LOI (loss of imprinting) and MOI (maintenance of methylation) determined using RFLP analysis of 8 imprinted genes in 74 samples of ovarian cancers and 21 cell lines

Hiura et al. BMC Medical Genomics 2012 5:8   doi:10.1186/1755-8794-5-8

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