Table 1 |
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Frequencies of LOH, LOI and MOI in human ovarian cancers. |
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(A) Ovarian cancer tissues |
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|
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|
H19/ R sal |
IGF2/ Apal |
KCNQ1/ Smal |
LIT1/ R sal |
GTL2/ T aal |
PEG1/ AFlll |
PEG3/ Mnll |
NDN/ Mbol |
|
|
|
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|
Heterozygosity |
58.5 (41/70) |
47.1 (33/70) |
55.5 (40/72) |
16.2 (12/74) |
58.3 (42/72) |
50.0 (37/74) |
34.2 (25/73) |
41.8 (31/74) |
|
LOH |
4.8 (2/41) |
9.0 (3/33) |
5.0 (2/40) |
0.0 (0/12) |
7.1 (3/42) |
8.1 (3/37) |
4.0 (1/25) |
0.0 (0/31) |
|
LOI |
29.2 (12/41) |
45.4 (15/33) |
12.5 (5/40) |
16.6 (2/12) |
23.8 (10/42) |
45.9 (17/37) |
8.0 (2/25) |
6.4 (2/31) |
|
MOI |
56.0 (23/41) |
33.3 (11/33) |
77.5 (31/40) |
83.3 (10/12) |
66.6 (28/42) |
45.9 (17/37) |
84.0 (21/25) |
93.5 (29/31) |
|
ND |
9.7 (4/41) |
12.1 (4/33) |
5.0 (2/40) |
0.0 (0/12) |
2.3 (1/42) |
0.0 (0/37) |
4.0 (1/25) |
0.0 (0/31) |
|
(B) Cell lines |
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|
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Heterozygosity |
19.0 (4/21) |
14.2 (3/21) |
33.3 (7/21) |
14.39 (3/21) |
23.8 (5/21) |
42.8 (9/21) |
23.8 (5/21) |
23.8 (5/21) |
|
LOI |
0/4 |
2/3 |
3/7 |
1/3 |
2/5 |
3/9 |
0/5 |
0/5 |
|
MOI |
4/4 |
1/3 |
4/7 |
2/3 |
3/5 |
6/9 |
5/5 |
5/5 |
|
|
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|
Percents of LOH (loss of heterozygosity), LOI (loss of imprinting) and MOI (maintenance of methylation) determined using RFLP analysis of 8 imprinted genes in 74 samples of ovarian cancers and 21 cell lines |
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|
Hiura et al. BMC Medical Genomics 2012 5:8 doi:10.1186/1755-8794-5-8 |
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