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Subtypes of primary colorectal tumors correlate with response to targeted treatment in colorectal cell lines

Andreas Schlicker1, Garry Beran3, Christine M Chresta3, Gael McWalter4, Alison Pritchard3, Susie Weston4, Sarah Runswick4, Sara Davenport3, Kerry Heathcote3, Denis Alferez Castro3, George Orphanides3, Tim French4* and Lodewyk FA Wessels125*

Author Affiliations

1 Division of Molecular Carcinogenesis, The Netherlands Cancer Institute, Amsterdam, The Netherlands

2 Faculty of EEMCS, Delft University of Technology, Delft, The Netherlands

3 Oncology iMed, AstraZeneca R&D, Alderley Park, Macclesfield, United Kingdom

4 Personalised Healthcare and Biomarkers Group, AstraZeneca R&D, Alderley Park, Macclesfield, United Kingdom

5 Department of Molecular Carcinogenesis, Plesmanlaan 121, Amsterdam, 1066CX, The Netherlands

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BMC Medical Genomics 2012, 5:66  doi:10.1186/1755-8794-5-66

Published: 31 December 2012

Additional files

Additional file 1:

Supplementary analysis and results. Tables S1-S4, S13-S14, S16, and Additional file 1: Figure S1, Additional file 1: Figure S2, Additional file 1: Figure S3 and Additional file 1: Figure S4.

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Additional file 2:

Table S5. Probe sets contained in the Type 1 gene signature.

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Additional file 3:

Table S6. Probe sets contained in the Type 2 gene signature.

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Additional file 4:

Table S7. Probe sets contained in the Subtype 1.1 gene signature.

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Additional file 5:

Table S8. Probe sets contained in the Subtype 1.2 gene signature.

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Additional file 6:

Table S9. Probe sets contained in the Subtype 1.3 gene signature.

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Additional file 7:

Table S10. Probe sets contained in the Subtype 2.1 gene signature.

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Additional file 8:

Table S11. Probe sets contained in the Subtype 2.2 gene signature

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Additional file 9:

Table S12. Results of stratifying different colorectal cancer datasets.

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Additional file 10:

Table S15. Pharmacological response data for cell line panel AZCL.

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