Open Access Research article

Adipose Co-expression networks across Finns and Mexicans identify novel triglyceride-associated genes

Blake E Haas1, Steve Horvath12, Kirsi H Pietiläinen34, Rita M Cantor1, Elina Nikkola1, Daphna Weissglas-Volkov1, Aila Rissanen5, Mete Civelek6, Ivette Cruz-Bautista7, Laura Riba8, Johanna Kuusisto9, Jaakko Kaprio10115, Teresa Tusie-Luna8, Markku Laakso9, Carlos A Aguilar-Salinas7 and Päivi Pajukanta1*

Author Affiliations

1 Department of Human Genetics and David Geffen School of Medicine at UCLA, Gonda Center, Room 6335B, 695 Charles E. Young Drive South, Los Angeles, California, 90095-7088, USA

2 Department of Biostatistics, David Geffen School of Medicine at the University of California, Los Angeles, USA

3 Obesity Research Unit, Department of Medicine, Division of Endocrinology, Helsinki University Central Hospital, and University of Helsinki, Helsinki, Finland

4 Institute for Molecular Medicine FIMM, University of Helsinki, Helsinki, Finland

5 Obesity Research Unit, Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland

6 Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles, USA

7 Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubiran, Mexico City, Mexico

8 Molecular Biology and Genomic Medicine Unit, Instituto Nacional de Ciencias Médicas y Nutrición, Salvador Zubiran, and Instituto de Investigaciones Biomédicas de la UNAM, Mexico City, Mexico

9 Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland

10 Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland

11 Hjelt Institute, Department of Public Health, University of Helsinki, Helsinki, Finland

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BMC Medical Genomics 2012, 5:61  doi:10.1186/1755-8794-5-61

Published: 6 December 2012

Additional files

Additional file 1:

Clinical characteristics of the Finnish and Mexican sets of samples. Additional data file 1 is a table listing the clinical characteristics of the Finnish and Mexican sets of samples.

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Open Data

Additional file 2:

The WGCNA results show that the yellow module is associated with serum TG levels in the Mexican TG cases/controls. Additional data file 2 is a figure of the WGCNA results in the Mexican sets of samples.

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Open Data

Additional file 3:

The WGCNA results indicate that the brown module is associated with serum TG levels in the METSIM TG cases/controls. Additional file 3 is a figure of the WGCNA results in the METSIM sets of samples.

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Open Data

Additional file 4:

The Finnish Twin WGCNA blue TG module is moderately preserved in the METSIM TG case/control study sample. Additional file 4 is the module preservation results for the Finnish twin and Mexican sets of samples.

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Additional file 5:

The 34 genes found in the Finnish twin, METSIM, and Mexican TG modules are enriched for immunity and inflammation genes. Additional file 5 is a table of the significant DAVID gene enrichment results.

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Additional file 6:

List of the 34 genes that overlap in all three WGCNA triglyceride modules in the Finnish Twins, METSIM, and Mexican sets of samples. Additional file 6 is a table describing the relevance of the TG module overlap genes to CHD-related traits.

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Open Data

Additional file 7:

The TG metaGWAS results in the ARHGAP9 region (+/− 500kb) utilizing the publicly available data from Teslovich et al. 2012. Additional file 7 is a figure illustrating the GWAS results in the ARHGAP9 region from a prior TG GWAS.

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Additional file 8:

The TG metaGWAS results in the LST1 region (+/− 500kb) utilizing the publicly available data from Teslovich et al. 2010. Additional file 8 is a figure illustrating the GWAS results in the LST1 region from a prior TG GWAS.

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Open Data