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Open Access Research article

Soft tissue sarcoma subtypes exhibit distinct patterns of acquired uniparental disomy

Musaffe Tuna1*, Zhenlin Ju2, Christopher I Amos3 and Gordon B Mills4

Author Affiliations

1 Department of Epidemiology, Unit 1340, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030-4009, USA

2 Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

3 Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

4 Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

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BMC Medical Genomics 2012, 5:60  doi:10.1186/1755-8794-5-60

Published: 5 December 2012

Additional files

Additional file 1:

Table S1. SNP microarray data summary.

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Additional file 2:

Figure S1. Distribution of aUPD regions in all soft tissue sarcoma samples. Each brown line represents aUPD region in each sample.

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Additional file 3:

Figure S2. The percentage of aUPD in (A) each subtype of STS and (B) each subgroup of liposarcoma.

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Additional file 4:

Figure S3. The frequency of aUPD in translocation and non-translocation driven soft tissue sarcomas. The frequency of (A) total aUPD, (B) telomeric aUPD, (C) centromeric aUPD, (D) segmental aUPD, (E) whole chromosome aUPD in non-translocation and translocation driven tumors.

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Additional file 5:

Table S2. Properties of recurrent aUPD regions in tumor samples of aRMS, GIST, leiomyosarcoma, myxofibrosarcoma, and pleomorphic liposarcoma tumor samples

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Additional file 6:

Table S3. aUPD regions with homozygous deletions and focal amplifications in tumor samples of soft tissue sarcoma subtypes.

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