Table 1

Over-represented canonical pathways in genes that correlated with CPRS-R for IA, HI or both
Canonical pathways P-value
Canonical pathways associated with common IA-HI genes
IL-4 Signaling 1.10 x 10-4
B Cell Receptor Signaling 1.30 x 10-4
Axonal Guidance Signaling 9.43 x 10-4
T Cell Receptor Signaling 4.95 x 10-3
Glucocorticoid Receptor Signaling 8.09 x 10-3
Canonical pathways associated with HI-specific genes
Integrin Signaling 7.29 x 10-6
Toll-like Receptor Signaling 1.61 x 10-4
B Cell Receptor Signaling 1.77 x 10-4
Role of NFAT in Regulation of the Immune Response 2.71 x 10-4
Growth Hormone Signaling 4.71 x 10-4
Natural Killer Cell Signaling 8.54 x 10-4
Canonical pathways associated with IA-specific genes
B Cell Development 2.74 x 10-5
Antigen Presentation Pathway 4.93 x 10-3
Cardiac β-adrenergic Signaling 7.88 x 10-3
B Cell Receptor Signaling 1.02 x 10-2
Primary Immunodeficiency Signaling 1.40 x 10-2
GM-CSF Signaling 2.15 x 10-2

Tian et al.

Tian et al. BMC Medical Genomics 2012 5:49   doi:10.1186/1755-8794-5-49

Open Data