Open Access Research article

Correlations of gene expression with ratings of inattention and hyperactivity/impulsivity in tourette syndrome: a pilot study

Yingfang Tian12*, Boryana Stamova1, Bradley P Ander1, Glen C Jickling1, Joan R Gunther1, Blythe A Corbett3, Netty GP Bos-Veneman4, Pieter J Hoekstra4, Julie B Schweitzer3 and Frank R Sharp1

Author Affiliations

1 MIND Institute and Department of Neurology, University of California at Davis, 2805 50th St., Room 2434, Sacramento, CA, 95817, USA

2 Laboratory of Gene Therapy, College of Life sciences, Shaanxi Normal University, Xi'an, Shaanxi, China

3 MIND Institute and Department of Psychiatry, University of California at Davis, Sacramento, CA, USA

4 Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, Netherlands

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BMC Medical Genomics 2012, 5:49  doi:10.1186/1755-8794-5-49

Published: 30 October 2012

Additional files

Additional file 1:

Table S1. ADHD symptom related genes.

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Additional file 2:

Table S2-1. Canonical pathways with significant over-representation of genes that correlated with CPRS for IA, HI or both (p<0.05, |rp| >0.4). Table S2-2. Chromosomes significantly over-enriched with genes that correlated with CPRS IA, HI scales or both (p<0.05, |rp| >0.4).

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Additional file 3:

Figure S1. Co-expression analysis results of 24 common Inattention/ Hyperactivity/ Impulsivity (IA-HI) pathway-related probesets by using two-way clustering of gene-gene correlation data.

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Additional file 4:

Figure S2. Co-expression analysis results of 106 Hyperactivity/ Impulsivity (HI) pathway-related probesets by using two-way clustering of gene-gene correlation data.

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Additional file 5:

Figure S3. Co-expression analysis results of 48 Inattention (IA) pathway-related probesets by using two-way clustering of gene-gene correlation data.

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Additional file 6:

Table S3. The multiple probesets targted to a specific gene were highly correalted each other.

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