Table 1

GO biological processes enriched for both up and down regulated genes between parous and nulliparous breast samples
GO term ID GO term (p-value) Genes up-regulated in parous samples
GO:0007044 cell-substrate junction assembly (0.006) KRT5, LAMA3, LAMC2
GO:0007398 ectoderm development (0.002) COL7A1, KRT5, KRT15, LAMA3, LAMC2, NTF4, KLK7
GO:0008544 epidermis development (0.001) COL7A1, KRT5, KRT15, LAMA3, LAMC2, NTF4, KLK7
GO:0010160 formation of organ boundary(0.009) NTF4
GO:0031581 hemidesmosome assembly (0.000) KRT5, LAMA3, LAMC2
GO:0016071 mRNA metabolic process (0.000) CIRBP, RBMX, HNRNPA1, HNRNPA2B1, HNRNPD, LUC7L3, PNN, PRPF39, RBM25, SFPQ, SFRS1, SFRS5, SFRS7, PABPN1, PRPF4B
GO:0006397 mRNA processing (0.000) RBMX, HNRNPA1, HNRNPA2B1, LUC7L3, PNN, PRPF39, RBM25, SFPQ, SFRS1, SFRS5, SFRS7, PABPN1, PRPF4B
GO:0034059 response to anoxia (0.009) OXTR
GO:0016070 RNA metabolic process (0.006) DDX17, CHD2,C BX3, CIRBP, ZNF785, EZH2, L3MBTL, GATA3, RBMX, ZNF789, HNRNPA1, HNRNPA2B1, HNRNPD, LUC7L3, PNN, PRPF39, ZNF83, METTL3, CREBZF, RBM25, RBBP8, RPS24, CENPK, SFPQ, SFRS1, SFRS5, SFRS7, ZNF814, ZNF207, PABPN1, RUNX3, FUBP1, PRPF4B, HNRPDL
GO:0006396 RNA processing (0.000) DDX17, RBMX, HNRNPA1, HNRNPA2B1, HNRNPD, LUC7L3, PNN, PRPF39, RBM25, RPS24, SFPQ, SFRS1, SFRS5, SFRS7, PABPN1, PRPF4B, HNRPDL
GO:0008380 RNA splicing (0.000) RBMX, HNRNPA1, HNRNPA2B1, HNRNPD, LUC7L3, PNN, PRPF39, RBM25, SFPQ, SFRS1, SFRS5, SFRS7, PABPN1, PRPF4B
GO term ID GO term Genes down-regulated in parous samples
GO:0032859 activation of Ral GTPase activity (0.003) RALGAPA2
GO:0021534 cell proliferation in hindbrain (0.005) IGF1
GO:0009441 glycolate metabolic process (0.001) IGF1
GO:0042692 muscle cell differentiation (0.006) IGF1, SOX6
GO:0051450 myoblast proliferation (0.003) IGF1
GO:0006654 phosphatidic acid biosynthetic process (0.005) ABHD5
GO:0031325 positive regulation of cellular metabolic process (0.005) EBF1, IGF1, ABHD5, SOX6
GO:0045821 positive regulation of glycolysis (0.006) IGF1
GO:0051006 positive regulation of lipoprotein lipase activity (0.006) ABHD5
GO:0042523 positive regulation of tyrosine phosphorylation of Stat5 protein (0.009) IGF1
GO:0031329 regulation of cellular catabolic process (0.002) IGF1, ABHD5
GO:0043567 regulation of insulin-like growth factor receptor signaling pathway (0.007) IGF1
GO:0010660 regulation of muscle cell apoptosis (0.006) IGF1
GO:0032485 regulation of Ral protein signal transduction (0.003) RALGAPA2
GO:0010889 regulation of sequestering of triglyceride (0.006) ABHD5
GO:0033143 regulation of steroid hormone receptor signaling pathway (0.010) IGF1
GO:0090207 regulation of triglyceride metabolic process (0.008) ABHD5
GO:0043403 skeletal muscle tissue regeneration (0.009) IGF1
GO:0007264 small GTPase mediated signal transduction (0.005) IGF1, RASD1, RALGAPA2
GO:0035019 somatic stem cell maintenance (0.010) IGF1

Peri et al.

Peri et al. BMC Medical Genomics 2012 5:46   doi:10.1186/1755-8794-5-46

Open Data