Figure 1.

Clinical PAM50 RT-qPCR breast cancer training set. Hierarchical clustering of RT-qPCR data for the PAM50 classifier genes normalized to the 5 control genes using 171 FFPE procured breast samples. Statistical selection using SigClust identified the 5 significant groups previously identified and designated as Luminal A (dark blue), Luminal B (light blue), HER2-E (pink), Basal-like (red), and Normal (green). The 16 non-neoplastic samples (grey), from reduction mammoplasty and grossly uninvolved breast tissues, all Clustered together and away from the invasive cancers. SigClust identified 4 reduction mammoplasty samples (green) that were used to train the Normal subtype.

Bastien et al. BMC Medical Genomics 2012 5:44   doi:10.1186/1755-8794-5-44
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