Illustration of different dependency relations between certain SNPs in ARID5B and IKZF1 genes, gender and ALL susceptibility. Top panel: The “averaged structure” of the Bayesian networks including ALL susceptibility (red node), gender (purple node) and the SNPs of ARID5B (blue nodes) and IKZF1 (orange nodes). The width of the edges is proportional to their a posteriori probability. The probability of the edges is computed by averaging over the Bayesian networks visited by the MCMC process. See Methods. Bottom panel: The posterior probability of strong relevance (blue columns), edge (direct strong relevance, red columns), pure interaction (green columns), association (purple columns), transitive association (yellow columns) and confounded association (brown columns) of the variables to ALL susceptibility according to the BN-BMLA method.
Lautner-Csorba et al. BMC Medical Genomics 2012 5:42 doi:10.1186/1755-8794-5-42