Table 1

Clinicopathological characteristics of the NSCLC patients used in this study (n/a = data unavailable)
Variable Prognostic signature Chemotherapy-response signature
Training Series A (n = 332) Validation Series A (n = 264) Training Series B (n = 88) Validation Series B (n = 109)
Age: Median (SD) 65 (10) 64 (10) 62 (10) 69 (9)
Gender: Female, Male 155 (47 %), 177 (53 %) 141 (53 %), 123 (47 %) 51 (58 %), 39 (42 %) 30 (28 %), 79 (72 %)
AJCC Stage: I: 229 (69 %), II: 61 (18 %), III: 42 (13 %) I: 201 (75 %), II: 63 (25 %) I: 39 (44 %), II: 27 (31 %), III: 21 (24 %), IV: 1 (1 %) I: 57 (52 %), II: 52 (48 %)
Stage I: A/B 108, 121 93, 97 5, 34 n/a
Stage II: A/B 50, 11 13, 44 25, 3 n/a
Grade: 1/2/3/na 48 (14 %), 163 (49 %), 117 (35 %), 4 (<1 %) 58 (22 %), 94 (35 %), 62 (23 %), 53 (20 %) 10 (11 %), 40 (45 %), 36 (41 %), 2 (2 %) n/a
Histological subtype Adenocarcinoma: 332 (100 %) Adenocarcinoma: 264 (100 %) Adenocarcinoma: 88 (100 %) Adenocarcinoma: 47 (43 %), Large cell: 10 (9 %), Squamous: 52 (48 %)
Smoking history Never: 33 (10 %) Former: 181 (55 %), Current: 25 (8 %), Unknown: 90 (27 %) Never: 43 (16 %), Former/current: 170 (64 %), Unknown: 54 (20 %) Never: 14 (16 %) Former: 65 (74 %) Current: 7 (8 %) Unknown: 2 (2 %) n/a
Radiotherapy 0 13 (5 %) 45 (51 %) 0
Chemotherapy 0 0 88 (100 %) 49 (45 %)
Original publication(s): Sheddon et al. [10] Sheddon et al. [10] Takeuchi et al. [11] Zhu et al. [8] Bild et al. [12] Bhattacharjee et al. [13] Sheddon et al. [10] Zhu et al. [8]
Genomic platform: Affymetrix U133A Agilent custom array: 59 (22 %), Affymetrix U95A: 140 (53 %), U133A/Plus 2.0: 65 (25 %) Affymetrix U133A Affymetrix U133A
NCBI GEO ID(s) or data source NIH.gov1 GSE11969, GSE14814, GSE3141, http://broad.org/MRP/lung webcite and NIH.gov1 NIH.gov1 GSE14814
Disease specific death within 5 years 122 (37 %) 97 (37 %) 47 (53 %) 34 (31 %)

1https://array.nci.nih.gov/caarray/project/details.action?project.experiment.publicIdentifier=jacob-00182 webcite.

Van Laar

Van Laar BMC Medical Genomics 2012 5:30   doi:10.1186/1755-8794-5-30

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