Association between the 160-gene prognostic signature, clinical and survival information in 301 untreated lung adenocarcinoma patients from Training Series A patients with at least 12 months follow-up). (A) Prognostic indexes range from −2 to +2 and are associated with an increase in DSS events, as indicated with a black line at (B). (C) Median-centered 160-gene expression profile used to compute the prognostic index (red = relative high expression, green = relative low expression). Each gene in the signature was chosen based on its statistically significant association with outcome, independent to age, stage, grade, gender and smoking history.
Van Laar BMC Medical Genomics 2012 5:30 doi:10.1186/1755-8794-5-30