Table 2

Putative target genes of differentially expressed miRNAs in NPC biopsies, which was consistent with the mRNA expression

miRNA microarray

cDNA microarray

miRNA

Expression

Target gene

expression


hsa-miR-1/206

up

API5, PCDH17, SMAD2, MTSS1, PDCD10, PDCD4, SMAD4

down

hsa-miR-141

up

PDCD4, MTSS1, ARHGAP24, SIAH1, PTEN

down

hsa-miR-149

up

TP63, SMAD2, CNTNAP2

down

hsa-miR-18a/b

up

DICER1, GIGYF2, STK4, RABGAP1, NOTCH2, NEDD9, ATM, SMAD2, NAV1, FOSL2, CAMKK2, STK4, BTG3, UBE2Z, IRF2, LIN54, HIF1A, RABGAP1, CCDC88A, ETV6, CCND2

down

hsa-miR-205

up

CADM1, MORF4L2, PTEN, SMAD1, SMAD4, TP53BP2

down

hsa-miR-544

up

AKT2, CADM1, CDH1, SMAD4

down

hsa-miR-99a/b

up

BMPR2, IGF1R, THAP2

down

hsa-miR-203

down

BCL2L2, ESR1, HBEGF, HBP1, HSPB8, IGFBP5, ITGA2, LPP, MAP3K1 MKL2, MLLT4, SOCS3

up

hsa-miR-222

down

ESR1, ITGB8, MBD2, MIA3, MLL, SOCS3, TET2

up

hsa-miR-29a/c

down

BCL2L2, HBEGF, HBP1, HSPG2, ITGB1, LAMC2, LTBR, MIB1, MLF1, MMP2, NDST1, SVEP1

up

hsa-miR-34b

down

BTRC, CTNNA1, CUL3, CYLD, ESR1, HIPK1, ITGA2, ITM2B, MKL2, MXD1, PAPD5, PPP1CB, SMAD3

up

hsa-miR-34c-3p

down

DCBLD2, FOXN3, IKZF1, NPTN PAFAH1B1, USP10, YY1

up

hsa-miR-34c-5p

down

ARHGAP1, ARHGEF3, BCL11B, C16orf5, CNTNAP1, FOXN3, FUT8, IL6R, ITGB8, ITSN1, JAG1, MLL2, NDST1, NOTCH2, NPNT, PPFIA1, PTPRM, PVRL1, SERPINE1, VCL, YY1

up

hsa-miR-429

down

MIB1, MLL5, NDST1, RHOA, RND3

up


Luo et al. BMC Medical Genomics 2012 5:3   doi:10.1186/1755-8794-5-3

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