Table 2

Minimal common regions of recurrent (≥ 25%) copy number amplification and deletion
Aberration Position (Mb) Size (Mb) Frequency, n = 27 (%) Possible target genes
+1q42.3 233.85-233.86 0.02 7 (26%) -
+6p21.1 43.41-44.34 0.94 8 (30%) MRPL14, POLR1C, HSP90AB1, XPO5, MRPS18A
+6p12.2 52.22-52.43 0.20 7 (26%) MCM3
+6p12.2-p12.1 52.44-52.98 0.54 7 (26%) TMEM14A
+7p21.1 16.68-17.28 0.60 8 (30%) BZW2
+7p12.2 50.62-50.67 0.05 7 (26%) -
+7p12.1-p11.1 53.84-57.47 3.63 9 (33%) MRPS17, CCT6A
+7q11.21-q11.23 63.35-73.62 10.27 9 (33%) CLDN4, EIF4H, SBDS, WBSCR22
+7q11.23 73.63-75.81 2.18 9 (33%) MDH2
+7q21.12-q21.13 87.54-90.07 2.52 7 (26%) SRI, CLDN12
+7q21.2 91.91-92.53 0.62 7 (26%) -
+7q21.3-q22.1 97.67-100.86 3.19 9 (33%) PLOD3, POP7, ARPC1A, COPS6, BUD31
+8p11.21-q11.1 42.35-47.79 5.44 8 (30%) VDAC3
+8q11.1-q24.3 47.86-146.27 98.41 19 (70%) *
+13q13.3 39.19-39.28 0.10 7 (26%) -
+13q14.11 39.81-40.58 0.77 8 (30%) -
+20p13 0.19-0.71 0.52 7 (26%) -
+20p12.1-p11.23 17.53-17.98 0.46 8 (30%) -
+20p11.21 24.84-25.35 0.51 10 (37%) -
+20q11.21-q12 29.40-40.53 11.12 14 (52%) TPX2, RPN2, POFUT1, CHMP4B, TOP1
+20q12-q13.2 40.54-52.12 11.57 11 (41%) CTSA, SLPI, MYBL2, PI3, YWHAB, TOMM34, B4GALT5, PIGT, C20orf111
+20q13.33 57.96-62.15 4.19 10 (37%) PSMA7, C20orf11
−3p14.2 60.42-60.48 0.06 7 (26%) -
−6p25.3 1.86-2.02 0.16 9 (33%) -
−18q22.1 60.04-60.07 0.02 7 (26%) -

*, possible target genes at 8q11.1-q24.3 included GRINA, MYC, PRKDC, LAPTM4B, SQLE, FAM91A1, GGH, PPM2C, RAD21, MCM4, LACTB2, ENY2, SIAHBP1, UBE2V2, YWHAZ, RAB2, SLC25A32, MAL2, CHCHD7, LYPLA1, ATP6V1C1, TPD52, EIF3S6, INTS8, HRSP12, and ZFAND1. +, copy number amplification. −, copy number deletion

Cheng et al.

Cheng et al. BMC Medical Genomics 2012 5:14   doi:10.1186/1755-8794-5-14

Open Data