Concordant deregulation of candidate genes at 8q11.21 and 8q22.3. Expression of candidate genes located adjacent to MCM4 at 8q11.21 (A) and YWHAZ at 8q22.3 (B) shows the same trends as that of MCM4 and YWHAZ, respectively. (a) Schematic genome structures of neighboring candidate genes at 8q11.21 and 8q22.3; (b) Pearson’s correlation coefficients of expression log ratios among candidate genes; (c) Expression log ratio of the individual gene in each sample. Gain (−)/Gain (+) was referred to samples with or without gain at 8q11.21 or 8q22.3; Amp (+) was referred to samples with amplification at 8q11.21 or 8q22.3.
Cheng et al. BMC Medical Genomics 2012 5:14 doi:10.1186/1755-8794-5-14