Table 3 |
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|
Candidate genes whose methylation is correlated with birth weight |
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|
Data Set |
L1-regularized regression R2 1 |
Non-zero regressions/total "leave one out" regressions at maximum L1 R2 |
Tissue |
Genes in model |
Gene ID |
|
|
|||||
|
22 newborns, methylation at 1,536 CpGs assayed using Illumina's GoldenGate array |
0.78 |
21/22 |
Blood |
APOE |
Apolipoprotein E |
|
MSX1 |
Msh homeobox 1 |
||||
|
Placenta |
GRB10 |
Growth factor receptor-bound protein 10 |
|||
|
PGRMC1 |
Progesterone receptor membrane component 1 |
||||
|
RGS14 |
Regulator of G-protein signaling 14 |
||||
|
SHMT2 |
Serine hydroxymethyl transferase 2 (mitochondrial) |
||||
|
48 newborns, methylation at 27,578 CpGs assayed using Illumina's Infinium array |
0.50 |
44/48 |
Blood and placenta, as above |
Six genes, above |
|
|
48 newborns, methylation at 27,578 CpGs assayed using Illumina's Infinium array |
0.70 |
45/48 |
Blood |
ATP6AP1 |
Atpase, H + transporting, lysosomal accessory protein 1 |
|
PRSS21 |
Protease, serine, 21 (testisin) |
||||
|
RCOR1 |
REST co-repressor 1 |
||||
|
Placenta |
ANGPT4 |
Angiopoietin 4 |
|||
|
CDK2 |
Cyclin-dependent kinase 2 |
||||
|
EVPL |
Envoplakin |
||||
|
NAT8L |
FLJ37478: N-acetyltransferase 8-like (GCN5-related, putative) |
||||
|
48 newborns, methylation at 27,578 CpGs assayed using Illumina's Infinium array |
0.84 |
44/48 |
Blood and Placenta, as above |
All 13 genes from both experiments, combined |
|
|
|
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|
1 The maximum L1-regularized regression correlation obtained for the gene model in which more than 90% of the "leave one out" cross-validations exhibited non-zero regression parameters (third column) |
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|
Turan et al. BMC Medical Genomics 2012 5:10 doi:10.1186/1755-8794-5-10 |
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