Table 1

Correlation of mechanism-based candidate gene expression levels with birth weight

Gene Symbol

Transcript ID

HumanHT-12 v3 Expression

vs. Birth Weight % (R2)

Real Time RT-PCR Expression

vs. Birth Weight % (R2)

Cord Blood

(n = 48)

Placenta

(n = 48)

Cord Blood

Placenta


IGF1

ILMN_2056087

2.0E-04

0.017

nd

nd

ILMN_1709613

0.003

0.002

IGF1R

ILMN_1675048

0.009

0.045

nd

nd

IGF2

ILMN_1699867

1.3E-05

0.004

1.2E-04 (n = 190)

4.5E-04 (n = 254)

ILMN_2298035

0.008

0.001

ILMN_2413956

0.003

0.003

IGF2BP1

ILMN_1733807

0.007

1.0E-04

nd

nd

IGF2BP2

ILMN_1702447

0.003

0.016

0.022 (n = 119)

1.0E-07 (n = 114)

IGF2BP3

ILMN_1807423

0.056

0.007

nd

nd

IGF2R

ILMN_1807662

0.006

3.0E-04

0.005 (n = 194)

6.1E-04 (n = 241)

IGFBP1

ILMN_2387385

0.014

0.001

ne

0.052 (n = 150)

ILMN_1728445

0.001

0.001

IGFBP2

ILMN_1725193

0.006

0.031

ne

0.003 (n = 110)

IGFBP3

ILMN_1746085

0.007

0.002

ne

0.001 (n = 135)

ILMN_2396875

0.009

0.002

IGFBP4

ILMN_1665865

0.006

0.003

nd

nd

IGFBP5

ILMN_2132982

0.014

0.002

nd

nd

ILMN_1750324

0.001

0.003

IGFBP6

ILMN_1669362

0.001

0.009

nd

nd

IGFBP7

ILMN_2062468

2.5E-05

0.005

nd

nd

INS

ILMN_1666966

0.022

0.034

nd

nd

INSR

ILMN_1670918

0.058

0.031

nd

nd

INSRR

ILMN_1715374

0.007

3.9E-05

nd

nd

PHLDA2

ILMN_1671557

0.036

0.001

nd

nd

PLAGL1

ILMN_1815121

0.001

0.009

0.006 (n = 105)

0.013 (n = 136)

ILMN_2356955

0.014

0.004

IGF2/IGF2R*

n/a

n/a

0.002 (n = 186)

0.002 (n = 241)


Multiple entries represent data for multiple transcripts on the array. The best correlation obtained in each group is shown in bold

* Ratio IGF2/IGF2R expression

n/a = not applicable

nd = not done

ne = not expressed

Turan et al. BMC Medical Genomics 2012 5:10   doi:10.1186/1755-8794-5-10

Open Data