Additional file 6.
Derivation of the EMT signature used to clarify the biology characterizing PC1. The EMT signature was derived from a global gene expression analysis of 93 lung cancer cell lines first segregated by differential CDH1 and VIM expression. Right panel shows the relationship between EMT signature score and CDH1 probe intensities, the left panel shows the EMT signature score vs. VIM probe intensity. EMT signature is observed to be positively correlated to VIM and anticorrelated to CDH1.
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Loboda et al. BMC Medical Genomics 2011 4:9 doi:10.1186/1755-8794-4-9