Correlation of microRNA analysis (~700) with PC1/EMT across 49 colorectal cancers identified the MiR200 family as strongly, negatively correlated with PC1/EMT (upper plots). The Mir 200 family has been linked to inhibition of EMT (promotion of the epithelial phenotype) through inhibition of Zeb 1 & 2, known transcriptional repressors of CDH1. Waterfall plots show MiR 200 over-expression is correlated with more tumors classified as epithelial than mesenchymal and Mir 200 under-expression is correlated with fewer epithelial than mesenchymal tumors (lower plots).
Loboda et al. BMC Medical Genomics 2011 4:9 doi:10.1186/1755-8794-4-9