Table 2

Subsets of angiogenic genes associated with LV function.

Cluster

Protein number

Interaction number

MCODE score*

Genes

1

3

4

1

TGFBR1, TGFBR2, CLU

2

5

7

1

TGFBR1, TGFBR2, CLU, MAP3K7, FOS

3

10

16

1.3

TGFBR1, TGFBR2, CLU, MAP3K7, FOS, SUMO4, STAT1, PTK2, BMX, CAV1

4

12

20

1.42

TGFBR1, TGFBR2, CLU, MAP3K7, FOS, SUMO4, STAT1, PTK2, BMX, CAV1, ITK, PAK1,

5

13

22

1.38

TGFBR1, TGFBR2, CLU, MAP3K7, FOS, SUMO4, STAT1, PTK2, BMX, CAV1, ITK, PAK1, PTGS2

6

16

27

1.37

TGFBR1, TGFBR2, CLU, MAP3K7, FOS, SUMO4, STAT1, PTK2, BMX, CAV1, ITK, PAK1, PTGS2, FYN, LCK, CD55

7

21

34

1.38

TGFBR1, TGFBR2, CLU, MAP3K7, FOS, SUMO4, STAT1, PTK2, BMX, CAV1, ITK, PAK1, PTGS2, FYN, LCK, CD55, ATP5B, SRC, MYOC, ANXA2, PLG

8

28

44

1.32

TGFBR1, TGFBR2, CLU, MAP3K7, FOS, SUMO4, STAT1, PTK2, BMX, CAV1, ITK, PAK1, PTGS2, FYN, LCK, CD55, ATP5B, SRC, MYOC, ANXA2, PLG, SOD1, BCL2, MAPK14, SMAD7, SHC1, MME, ADM

9

35

55

1.34

TGFBR1, TGFBR2, CLU, MAP3K7, FOS, SUMO4, STAT1, PTK2, BMX, CAV1, ITK, PAK1, PTGS2, FYN, LCK, CD55, ATP5B, SRC, MYOC, ANXA2, PLG, SOD1, BCL2, MAPK14, SMAD7, SHC1, MME, ADM, CFH, THBS1, KNG1, PLAUR, PRKCA, RAB25

*MCODE cluster score = density * number of nodes.

Devaux et al. BMC Medical Genomics 2011 4:83   doi:10.1186/1755-8794-4-83