Gene Set Enrichment Analysis (GSEA) of expression profiles of blood cells from MI patients. Gene expression profiles of blood cells from two groups of 16 MI patients having either high EF (> 40%) or low EF (≤ 40%) were obtained by 25,000 genes oligonucleotide microarrays. After normalization and filtering steps, expression data were analyzed by GSEA and are visualized by heat-maps. Colors (red, pink, light blue, dark blue) show the range of expression values (high, moderate, low, lowest, respectively). Black boxes denote missing values. (A) Expression ranges of the 50 most differentially expressed genes showing distinct transcriptomic biosignatures between patients with high and low EF. (B) Among the 525 differentially expressed genes between high and low EF patients, 28 genes were involved in angiogenesis according to the Entrez Gene database resource: 20 genes were up regulated in the low EF group and 8 genes were up regulated in the high EF group. A heat-map representing the expression values of these 28 genes is shown.
Devaux et al. BMC Medical Genomics 2011 4:83 doi:10.1186/1755-8794-4-83