Table 2 |
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|
KEGG pathways enriched by DEGs, all DEmiRNA target genes and all DEmiRNA target DEGs. |
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|
All DEGs |
All DEmiRNA predicted targets |
DEGs that are DEmiRNA predicted targets |
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|
|
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|
KEGG pathway |
Up-regulated DEGs |
Down-regulated DEGs |
All targets of down-regulated DEmiRNAs |
All targets of up-regulated DEmiRNAs |
DEG targets of down-regulated DEmiRNAs |
DEG targets of up-regulated DEmiRNAs |
|
|
|
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|
Signal Transduction |
Calcium signaling pathway |
4.0E-01 |
1.0E + 00 |
4.6E-04 |
2.7E-03 |
4.1E-02 |
9.5E-01 |
|
ErbB signaling pathway |
3.4E-01 |
3.5E-01 |
9.3E-05 |
6.4E-08 |
1.3E-01 |
4.2E-01 |
|
|
Hedgehog signaling pathway |
4.2E-02 |
4.7E-01 |
2.8E-02 |
6.2E-04 |
8.1E-03 |
6.1E-01 |
|
|
Jak-STAT signaling pathway |
6.0E-01 |
3.9E-01 |
7.6E-02 |
7.6E-02 |
1.0E-01 |
2.5E-01 |
|
|
MAPK signaling pathway |
2.0E-01 |
9.5E-02 |
1.7E-08 |
1.3E-16 |
1.3E-01 |
1.6E-01 |
|
|
mTOR signaling pathway |
5.3E-01 |
2.0E-01 |
1.1E-02 |
2.6E-07 |
1.0E + 00 |
5.3E-02 |
|
|
Notch signaling pathway |
7.2E-02 |
1.6E-01 |
1.4E-01 |
5.4E-03 |
2.9E-01 |
5.4E-01 |
|
|
Phosphatidylinositol signaling system |
2.5E-01 |
8.6E-01 |
8.2E-05 |
3.9E-06 |
1.1E-01 |
3.6E-01 |
|
|
TGF-beta signaling pathway |
3.4E-01 |
5.5E-01 |
4.3E-08 |
1.9E-06 |
4.8E-01 |
1.0E + 00 |
|
|
VEGF signaling pathway |
2.5E-01 |
1.2E-01 |
7.4E-02 |
2.2E-03 |
4.3E-01 |
3.6E-02 |
|
|
Wnt signaling pathway |
4.9E-03 |
7.4E-03 |
1.4E-05 |
1.3E-14 |
7.2E-04 |
3.3E-03 |
|
|
|
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|
Signaling Molecules and interactions |
Cell adhesion molecules (CAMs) |
8.1E-02 |
9.4E-01 |
8.4E-01 |
2.9E-01 |
7.4E-02 |
6.5E-01 |
|
ECM-receptor interaction |
5.7E-07 |
9.0E-01 |
2.7E-04 |
9.3E-06 |
3.1E-03 |
1.0E + 00 |
|
|
|
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|
Behavior |
Circadian rhythm - mammal |
1.0E + 00 |
1.1E-01 |
3.1E-02 |
1.6E-02 |
1.0E + 00 |
1.9E-01 |
|
|
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|
Cell Communication |
Adherens junction |
1.2E-01 |
9.7E-01 |
1.1E-04 |
1.1E-09 |
4.3E-01 |
1.0E + 00 |
|
Focal adhesion |
9.6E-09 |
5.5E-01 |
1.4E-07 |
8.8E-17 |
3.1E-03 |
8.5E-01 |
|
|
Gap junction |
3.7E-01 |
1.0E + 00 |
1.1E-02 |
4.7E-06 |
2.8E-02 |
1.0E + 00 |
|
|
Tight junction |
4.7E-01 |
3.9E-01 |
8.3E-03 |
3.9E-06 |
6.3E-01 |
1.8E-01 |
|
|
|
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|
Cell Growth and Death |
Apoptosis |
8.1E-01 |
4.4E-02 |
2.7E-02 |
6.5E-03 |
1.0E + 00 |
4.3E-01 |
|
Cell cycle |
9.4E-01 |
3.5E-01 |
7.3E-03 |
1.4E-01 |
6.2E-01 |
8.9E-01 |
|
|
p53 signaling pathway |
6.8E-01 |
8.6E-02 |
1.5E-02 |
4.4E-03 |
4.0E-01 |
3.1E-01 |
|
|
|
|||||||
|
Cell Motility |
Regulation of actin cytoskeleton |
1.9E-01 |
5.0E-01 |
2.2E-05 |
1.4E-12 |
4.7E-01 |
4.8E-01 |
|
|
|||||||
|
Circulatory System |
Vascular smooth muscle contraction |
5.6E-06 |
1.0E + 00 |
3.0E-03 |
1.0E-03 |
1.6E-04 |
1.0E + 00 |
|
|
|||||||
|
Development |
Axon guidance |
6.8E-02 |
6.9E-01 |
1.2E-08 |
3.9E-15 |
6.7E-02 |
3.6E-01 |
|
Dorso-ventral axis formation |
5.8E-01 |
1.0E + 00 |
4.0E-04 |
1.3E-02 |
1.0E + 00 |
1.0E + 00 |
|
|
|
|||||||
|
Endocrine System |
Adipocytokine signaling pathway |
3.9E-01 |
1.5E-04 |
2.0E-02 |
2.3E-05 |
3.9E-01 |
7.4E-04 |
|
GnRH signaling pathway |
2.6E-01 |
4.8E-01 |
4.8E-03 |
1.6E-04 |
3.8E-02 |
2.4E-01 |
|
|
Insulin signaling pathway |
2.2E-03 |
1.9E-02 |
2.6E-03 |
7.0E-11 |
7.9E-02 |
2.5E-02 |
|
|
Melanogenesis |
6.8E-01 |
9.9E-01 |
2.9E-03 |
1.2E-06 |
1.7E-01 |
8.2E-01 |
|
|
PPAR signaling pathway |
1.0E + 00 |
1.9E-01 |
6.6E-01 |
8.1E-01 |
1.0E + 00 |
2.6E-02 |
|
|
|
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|
With genes in each module of the network, pathway enrichment analysis was performed using one-sided Fisher exact test. The significance level of p-value is represented by regular (0.01~0.1), bold (0.0001~0.01) and bold-italic (<0.0001) fonts. |
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|
Cho et al. BMC Medical Genomics 2011 4:8 doi:10.1186/1755-8794-4-8 |
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