Table 3

Some pathways and functional terms overrepresented among FSHD-dysregulated genes.

Functional termsa

Mb

or Mt

No. of up- or

dnreg. genes

Ratiob


RNA-induced silencing complex

Mt

4 dn

0.80

Mb

1 dn

0.20


Fatty acid elongation in mitochondria

Mb

7 up

0.44

Mt

2 up

0.13


Extracellular matrix

Mt

35 up, 1 dn

0.30

Mb

4 up, 2 dn

0.05


NRF2-mediated oxidative stress response

Mt

15 up, 7 dn

0.13

Mb

7 up

0.04


HIF1α Signaling

Mt

6 up, 7 dn

0.12

Mb

5 up

0.05


Regulation of actin-based motility by Rho

Mt

9 up, 3 dn

0.10

Mb

6 up

0.07


Mitochondrial matrix

Mt

18 up, 5 dn

0.11

Mb

22 up, 1 dn

0.11


Oxidative phosphorylation

Mt

18 up

0.16

Mb

11 up

0.09


Induction of apoptosis

Mt

13 up, 5 dn

0.09

Mb

8 up, 2 dn

0.05


Anti-apoptosis

Mt

16 up, 3 dn

0.10

Mb

4 up

0.02


aOverrepresented functional terms for genes up- or downregulated (p < 0.01) in FSHD vs. control myoblasts (Mb) or myotubes (Mt) were identified by bioinformatics programs. Details and the names of the dysregulated genes are given in Additional File 8 Table S5.

bThe number of genes for a given pathway or GO-term that were up- or downregulated in FSHD vs. control myogenic cells/the total number of genes for that pathway or GO-term that were included in the microarray.

Tsumagari et al. BMC Medical Genomics 2011 4:67   doi:10.1186/1755-8794-4-67

Open Data