Some muscle-associated genes are downregulated in FSHD myogenic cells while others are not. Fold changes in RNA signal were determined by identical expression profiling of FSHD and control myoblast and myotube preparations and 19 diverse non-muscle cell types (See Additional File 1 and Additional File 2 for detailed descriptions of samples). All p-values for microarray data were adjusted for multiple comparisons; pink, significantly upregulated at p < 0.01; green, significantly downregulated at p < 0.01. Myotube (Mt) data are shown for the genes with much stronger expression at the myotube stage than at the myoblast stage. Myoblast data are given for MYOD1, MYF5, and MYF6.
Tsumagari et al. BMC Medical Genomics 2011 4:67 doi:10.1186/1755-8794-4-67