The number of genes with myogenesis-specific expression: comparison of control and FSHD cells with 19 non-muscle cell types. A. The number of genes with FC > 2 (p < 0.01) in comparison of both control and FSHD cells with 19 non-muscle cell types. The total number of genes with FC > 2 (p < 0.01) for upregulation or downregulation in control myoblasts or myotubes vs. 19 diverse non-muscle cell cultures is given in parentheses. The divisions in the bars show the overlap of the set of myogenesis-specific genes in FSHD myoblasts or myotubes with that of the corresponding control myogenic cells. B. The number of genes with overlapping myogenesis specificity for FSHD and control myoblasts and myotubes but relaxing the stringency for the FSHD myogenic cells to only significant myogenesis-specific differences (p < 0.01) without an FC specified while retaining the FC > 2 threshold for control myogenic cells.
Tsumagari et al. BMC Medical Genomics 2011 4:67 doi:10.1186/1755-8794-4-67