Additional file 4.

Heatmap depicting expression levels of probes in the prediction profile. A supervised heatmap was generated using R function heatmap from the R package stats. In the heatmap, low to high probe expression is shown from blue to yellow. The bars above and to the immediate left of the heatmap show whether samples are of the chondroblastic (red), fibroblastic (green), or of the osteoblastic (blue) subtype. The upper bar represents whether samples are biopsies (black), xenografts (magenta), or cell lines (cyan). The outer left bar depicts the regulation of a specific gene in the specific subtype, with yellow for overexpression and blue for downregulation. For the genes ACAN and COL2A1, two probes are present in the prediction profile. These are indicated as ACAN_1, ACAN_2, COL2A1_1, and COL2A1_2 (probes 4780368, 5910377, 6110722, and 7150719, respectively).

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Kuijjer et al. BMC Medical Genomics 2011 4:66   doi:10.1186/1755-8794-4-66