Minimal transcriptional regulatory networks in gliomas. (A) Minimal network for pilocytic astrocytoma. Transcription factors (TF) are shown by large solid circles, target genes are shown by small solid circles. Interactions between TF-TF and TF-target are shown by directed edges. Genes overexpressed in PA relative to non-malignant brain tissue are shown in red, while genes whose expression is lower in PA are shown in green. (B) Similar relationships depicted in the minimal network assembled from the oligodendroglioma gene expression data set. (C) Relationships that are unique to PA as compared to the minimal network assembled for GBM.
Deshmukh et al. BMC Medical Genomics 2011 4:57 doi:10.1186/1755-8794-4-57