Open Access Research article

Identification of transcriptional regulatory networks specific to pilocytic astrocytoma

Hrishikesh Deshmukh1, Jinsheng Yu1, Jahangheer Shaik1, Tobey J MacDonald2, Arie Perry1, Jacqueline E Payton1, David H Gutmann3, Mark A Watson1 and Rakesh Nagarajan1*

Author Affiliations

1 Department of Pathology and Immunology, Washington University School of Medicine, 660. S. Euclid Ave. St. Louis, MO, 63110, USA

2 Department of Pediatrics, Emory University, Atlanta, GA, 30322, USA

3 Department of Neurology, Washington University School of Medicine, 660. S. Euclid Ave. St. Louis, MO, 63110, USA

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BMC Medical Genomics 2011, 4:57  doi:10.1186/1755-8794-4-57

Published: 11 July 2011

Additional files

Additional file 1:

The 792 gene set that is differentially expressed in PAs along with each gene's expression differences when compared to the control are shown.

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Additional file 2:

PA network obtained as a result of step 3 in Figure 2. Transcription factors (TF) are shown by large solid circles, target genes are shown by small solid circles. Interactions between TF-TF and TF-target are shown by directed edges. Genes overexpressed in PA relative to non-malignant brain tissue are shown in red while genes whose expression is lower in PA are shown in green.

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Additional file 3:

Gene regulatory relationships in glioblastoma multiforme minimal network. The Transcription Factors (TFs) and respective relationships between their targets are shown.

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