Table 2

The Common Metastatic Signature

Number of

studies repeated

Up-regulated

in metastasis

Down-regulated

in metastasis


4 studies

Not significant

ACTG2

GJA1

NBL1

RARRES1

CASP7

GNG12

PAGE4

SELE

CSRP1

GSN

PAM

SLC12A4

CYR61

IER2

PCP4

SMTN

DPT

ISL1

PDE4D

SORBS1

DSTN

JMJD3

PIGB

SYNPO2

FILIP1L

JUNB

PKIG

TCF21

FLNC

KRT15

PLA2G2A

TMEM49

FOSB

LUM

PLEKHC1

TPM1

FUCA1

MAPK1

PPP1R12A

TSC22D1

GADD45B

MFAP4

RAP1A

VCL

5 studies

EZH2

ACTA2

DKFZP564O0823

LMOD1

RBPMS

BMPR1A

DMN

MCL1

SPARCL1

CAMK2G

FBLN1

MGP

SPG20

CCND2

FHL1

NR4A1

TACC1

CNN1

FXYD3

NR4A3

TAGLN

CTGF

HBEGF

PPP1R12B

ZFP36

DIO2

KCNMA1

PYROXD1

6 studies

None

BTG2

KCNMB1

MYLK

JUND

MYH11

SOD3

8 studies

None

TPM2


The gene symbols of the genes in the metastatic signature are given with along with the number of studies in which it was significant.

Daves et al. BMC Medical Genomics 2011 4:56   doi:10.1186/1755-8794-4-56

Open Data