Table 3

GWA SNPs with confirmed allelic association with obesity in extension studies

Chr.

Gene

Effect allele*

Cohort**

Call rate (%)

Obese

Controls

P§§


GG/GT/TT

GG/GT/TT


10

KCNMA1

rs2116830G

1

98

121/35/4

87

91/59/9

76

5.0 × 10-04

2

99

314/126/9

84

153/74/13

79

0.019

3

99

1232/499/53

83

1108/522/61

81

0.018

4

98

684/232/25

85

348/161/16

82

0.024

5

97

598/263/26

82

1065/576/81

79

0.0017

6

100

318/125/9

83

295/128/12

84

0.35

Pooled

3267/1180/126

3060/1520/192

2.8 × 10-10

11

BDNF

rs988712G

1

91

104/53/4

81

86/67/10

73

0.0017

2

99

300/140/13

82

139/83/16

76

0.0095

3

99

1126/590/66

80

976/595/112

76

3.9E-05

4

98

609/283/34

81

273/199/50

71

2.2 ×10-9

5

95

540/290/41

79

942/642/106

75

0.0019

6

99

273/148/25

78

246/151/33

75

0.13

Pooled

2952/1504/183

2662/1737/327

5.2 × 10-17


* All SNPs are in HWE with P> 0.05. ** Details about cohorts are given in table 1. § Frequency of effect allele among obese cases and controls. §§ Allele frequencies were compared by Chi2-test.

Jiao et al. BMC Medical Genomics 2011 4:51   doi:10.1186/1755-8794-4-51

Open Data