Table 6

15 miRNAs and target genes in the cancer-related canonical pathways

Cancer related canonical pathway

PLS predicted Target genes in the respective pathways

The nos. of cancer related miRNAs associated with the mRNA targets


Protein Ubiquitination Pathway

PSMA3, PSMB2, PSMB4, PSMC2, PSMC4, PSMD8, UBE2I, USP22(8)

14


Polyamine Regulation in Colon Cancer

OAZ1, ODC1, PSMA3, PSMB2, PSMB4, PSMC2, PSMC4, PSMD8(8)

15


Purine Metabolism

ATP6V0B, GUK1, ITPA, POLR2H, PSMC2, PSMC4 (6)

11


Circadian Rhythm Signaling

BHLHE40(1)

2


Hypoxia Signaling in the Cardiovascular System

UBE2I(1)

4


Cdc42 Signaling

ARPC1B, CDC42SE1(2)

4


Pyrimidine Metabolism

ITPA, POLR2H (2)

7


mTOR Signaling

DDIT4, EIF3B (2)

7


NRF2-mediated Oxidative Stress Response

FTL, GSTP1, PPIB(3)

7


Xenobiotic Metabolism Signaling

FTL, GSTP1(2)

7


Li et al. BMC Medical Genomics 2011 4:44   doi:10.1186/1755-8794-4-44

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