Table 4

15 miRNAs and target genes involved in the cancer-related gene networks

Top Network

Target genes

Top functions

The nos. of miRNAs associated


Network 1

BHLHE40, CANX, CDC42SE1, GPX1, GPX4, GSTP1, MDK, MIF, MMP11, OAZ1, ODC1, PPIB, PRDX2, PSMA3, PSMB2, PSMB4, PSMC2, PSMC4, PSMD8, TGFBI, UBE2I

small molecule biochemistry, drug metabolism and tumor morphology

15


Network 2

ANXA2, CAPG, CLIC1, CPNE1, CSTB, DAP, EIF3B, GUK1, IFITM1, RPL34, RPS9, SLC7A11, SOX4, TBCD, TUFM, USP22

protein synthesis, cell signaling and interaction, and reproductive system function,

14


Network 3

ATP6V0B, BHLHE40, COTL1, CYBA, DDIT4, FTL, ITPA, LAPTM5, NEBL, NUDT1, RPS2, S100A11, SORD

genetic disorder, immunological disease and free radical scavenging

14


Network 4

ANXA2, ARPC1B, BUD31, GNPTG, GPATCH3, GTF3C1, NAP1L4, PHB, POLR2H, PUF60, UBA6, VKORC1, WDR36

gene expression, cellular development, cellular growth and proliferation

14


Li et al. BMC Medical Genomics 2011 4:44   doi:10.1186/1755-8794-4-44

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